Liquisolid Dosage System: A Novel Approach for Dosage formulation

Liquisolid system is a novel concept of dosage formulation for water insoluble drugs and lipophilic drugs via oral route. Formulation concept of liquisolid technology involves water insoluble drugs dissolved in suitable non-volatile liquid vehicles, and converted in to compact by blending with selective powder excipients. Liquisolid compacts are compressible powdered forms of liquid medications, and they are industrially applicable. The liquisolid technology allows the transformation of liquid systems into solid drug delivery systems such as tablets. The liquisolid approach has been successfully applied in release enhancement of low dose poorly soluble drugs. However, the formulation of high dose poorly soluble drugs is one of the limitations of this technique because of the high amount of liquid vehicle needed. Consequently, high amounts of carrier and coating material are required ultimately leading to an unacceptably high tablet weight.